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Description

GA521005: Fmoc-Ser(Glc(Ac)4-α-D)-OHC32H35NO14 657. 62 An Fmoc protected L serine building block carrying an D glucose residue, designed for solid phase peptide synthesis (SPPS) of glycopeptides. The N Fmoc group is removed under standard base conditions (piperidine) during chain elongation, while the free carboxylic acid is available for coupling to the growing resin bound peptide. The sugar hydroxyl groups are protected as four acetate esters (Ac4), which keep the glycan inert during

and inhibitor / activator studies

/ β-D-LacNAc-Ethyl-Azide / 2-Azidoethyl LacNAc

12 / An Fmoc-protected L-serine building block carrying a Neu5Acα2-6GalNAcα disaccharide

C43H51N3O19 / 913

Fmoc-Asn(beta-D-GlcNAc(Ac)3)-OH

bioavailability studies

Fmoc-Thr(α-Gal β(1-3)GalNAc)-OH

diagnostic screening

6-tetra-O-acetyl-α-D-galactopyranosyl)-L-serine

supplied as the sodium salt

the conserved core disaccharide of N-linked glycans

/ MUC4(1179-1194)-Tn(1183) / Mucin4